Past Symposia

November 2021

The CAUSALab Inaugural Event: Causal Inference from Real World Data in the Era of Covid-19

November 5, 2021 | 10:30am-3:00pm | Snyder Auditorium, Kresge G1

Watch on YouTube


Program

Welcome – Albert Hofman

The CAUSALab: A Center to Learn What Works – Miguel Hernán

The CAUSALab’s Response to Covid-19: Data science for decision making, chaired by Sonia Hernandez-Diaz

  • Vaccines for Covid-19 prevention: Comparative effectiveness and safety – Barbra Dickerman
  • Drug repurposing for COVID-19 prevention: The effects of old drugs on a new disease – Katherine Li
  • Nonpharmacological interventions for the treatment and prevention of Covid-19 – Arin Madenci / José Zubizarreta

Causal inference without randomized experiments: How do we know we are right? – James Robins
Panel Discussion – Issa Dahabreh, Miguel Hernán, Sara Lodi, and James Robins (moderated by Andrew Beam)

 

Spring 2020

Weighting for Causal Inference: Estimating the impact of a natural disaster on health outcomes?

February 7, 2020 | 3:45-5:15pm | TMEC 227 Amphitheater

Host: José R. Zubizarreta

Discussant: Jamie Robins

Moderator: Miguel Hernan

 

Fall 2019

Bugs and drugs: How (and how much) does changing antibiotic use, change antibiotic resistance?

November 1, 2019 | 3:45-5:15pm | 503, Ballard Room

Hosts: Marc Lipsitch and Yonatan Grad

Moderator: Mats J. Stensrud

Mobile Health: Which type of in-the-moment support is best provided to someone who is struggling with suicidal thoughts?

October 4, 2019 | 3:45-5:15pm | 503, Ballard Room

Co-Hosts: Susan Murphy and Matt Nock

Moderator: Miguel Hernán

 

Spring 2019

Machine Learning for Health: How can we better leverage machine learning to change the future of healthcare?

Friday May 3, 2019 | 3:45-5:15pm | Waterhouse Faculty Room, 106 Gordon Hall

Hosts: Andrew Beam, Sherri Rose, and David Sontag

Introduction by Michael Oberst

Moderator: Miguel Hernán

Click here to view the May 2019 flyer.

What Problems Can Electronic Health Records Solve? The strengths and pitfalls of EHR data

Friday April 5, 2019 | 3:45-5:15pm | Ballard Room, Countway Library

Hosts: James Floyd, Jessica Chubak, and Goodarz Danaei

Moderator: Miguel Hernán

Click here to view the April 2019 flyer.

Do the results from a trial apply to my target population? Transporting causal inferences from randomized trials to new populations

Friday March 8, 2019 | 3:45-5:15pm | 106 Gordon Hall

Presentations by: Elvira D’Andrea, Irina Degtiar, and Sarah Robertson 

Hosts: Issa Dahabreh and Mehdi Najafzadeh

Moderator: Miguel Hernán

Co-sponsored by the Center for Evidence Synthesis in Health at Brown University and the Division of Pharmacoepidemiology & Pharmacoeconomics at Brigham and Women’s Hospital.

 

Using Real-World Data to Emulate Randomized Trials – Target Trial Design and Implementation

Friday February 1, 2019 | 3:45-5:15pm | 106 Gordon Hall

Heard about target trials and curious to learn more? Join us for a collaborative group exercise in designing target trials! Using examples from pharmacoepidemiology and clinical epidemiology, this workshop will provide a practical tutorial on conceiving and designing target trials, and avoiding common pitfalls encountered when using that target trial to guide study design and analyses in observational data.

Facilitators: Barbra Dickerman, Lucia Petito, & Kerollos Wanis

Hosts: Sara Lodi & Miguel Hernan

Co-sponsored by the Boston University School of Public Health Department of Biostatistics

Click here to view the February 2019 flyer.

 

Fall 2018

Workshop: Crowdsourcing Causal Graphs – A hackathon for causal DAGs

Friday December 7, 2018 | 3:45-5:15pm | 261 Tosteson Medical Education Center – 2nd Floor Atrium

Heard about causal graphs or DAGs and curious to know more? Join us for a collaborative, hands-on exercise in building causal graphs! Using an example from psychiatric epidemiology, this workshop will provide a practical tutorial on summarizing expert knowledge into a causal graph and using that graph to think about study design and analyses.

Facilitators: Eleanor Murray, Jaimie Gradus, & Matthew Fox

Presenters: Louisa Hills Smith & Laura Ann Sampson

Host: Sonia Hernandez-Diaz

Co-sponsored by Boston University School of Public Health Department of Epidemiology

Click here to view the December 2018 flyer.

 

Workshop: Causal Survival Analysis in Follow-Up Studies

Friday November 2, 2018 | 3:45-5:30pm | Ballard Room, Countway Library

Do you work with survival data? Are you wary of the hazards of hazard ratios? Learn how to estimate survival outcomes adjusted for baseline and time-varying confounders! This practical, hands-on workshop will cover estimating survival curves, cumulative incidence differences & ratios, and inverse probability-weighted hazard ratios for intention-to-treat effects and per-protocol treatment effects for randomized trials and observational data. Bring a laptop with R or SAS, we’ll provide the code and real data!

Facilitated by Lucia Petito & Eleanor Murray

Host: Miguel Hernán

Click here to view the November 2018 flyer.

 

Should Women Use Acetaminophen during Pregnancy? A discussion of analytic choices and improbable study findings.

Friday October 5, 2018 | 3:45-5:30pm | Ballard Room, Countway Library

Currently, acetaminophen is the only over-the-counter pharmaceutical drug approved by the Food and Drug Administration (FDA) for women to use during pregnancy for pain relief or fever reduction. However, recent studies done in cohorts around the world have found an increased risk of neurocognitive outcomes (e.g. ADHD diagnosis, slower language development, lower IQ) in children of women who used acetaminophen during pregnancy. In 2014, the FDA reviewed this research and deemed the level of evidence not high enough to change the current recommendation. In this symposium, we will discuss possible sources of bias in these analyses of cohort data that may have influenced study findings (unmeasured confounding, measurement error, selection bias), what the regulatory implications of these findings are, and how to proceed when study findings polarize the scientific community.

Presentations by: Samantha Parker, Mollie Wood, & Yanmin Zhu

Panel members: Sonia Hernandez-Diaz, Samantha Parker, Martha Werler, Mollie Wood, & Yanmin Zhu

Host: Miguel Hernán

Click here to view the October 2018 flyer.

 

Spring 2018

The Data Science of Implementation Science

Friday, May 4, 2018 | 3:45-5:30pm | Ballard Room, Countway Library

Implementation science aims to study the process by which original research becomes widely disseminated. It has been described as “a systematic, scientific approach to ask and answer questions about how to get ‘what works’ to people who need it with greater speed, fidelity, efficiency, quality, and relevant coverage.” However, there are many analytic challenges to consider when assessing the effectiveness of the implementation of a public health intervention, which may, at many stages, not be what the original research recommended. In this symposium, we will 1) describe the basic principles of implementation science, 2) provide a concrete example of the public health significance of an implementation science study, and 3) demonstrate some of the methodological work underway to address such challenges.

Presentations by: Dale Barnhart, John Naslund, & Daniel Nevo

Panel members: Dale Barnhart, Miguel HernánJohn Naslund, Daniel Nevo,  & Donna Spiegelman

Host: Lucia Petito

Click here to view the May 2018 flyer

 

Did your mother’s prenatal diet affect you? Using lifecourse data to answer intergenerational questions

Friday, April 6, 2018 | 3:45-5:30pm | Ballard Room, Countway Library

Co-hosted by the Division of Chronic Disease Research Across the Lifecourse (CoRAL) and the Program on Causal Inference

Many chronic childhood diseases are thought to originate in the early stages of human development. Prenatal diet is thought to be a modifiable risk factor that directly impacts child growth in utero. In this symposium, we plan to discuss 1) the evidence that supports the effect of prenatal diet on offspring childhood health outcomes, 2) how researchers use complex longitudinal surveys to conduct intergenerational research, and 3) how to incorporate causal inference ideas into future analyses.

Presentations by: Izzuddin ArisYu-Han Chiu, & Karen Switkowski

Panel members: Izzuddin Aris, Yu-Han Chiu, Miguel Hernán, Emily Oken, Karen Switkowski.

Host: Jessica Young

Evidence-Based Policy: How can we use health data to build better microsimulation models?

Friday, March 2, 2018 | 3:45-5:30pm | Ballard Room, Countway Library

Co-hosted by the Center for Health Decision Science and the Program on Causal Inference

Many health policy questions cannot be answered by conducting randomized trials or analyzing observational data. To address these questions, researchers have turned to microsimulation models, which incorporate data from varying sources. In this symposium, we aim to better understand: 1) the types of questions microsimulation models are used to answer, 2) the evidence used to create an individual-level microsimulation model, and 3) the connections between microsimulation models and the parametric g-formula, a causal inference technique. We will discuss recommendations for practical implementation of both methodologies.

Presentations by: Nicole Campos, Vidit Munshi, & Eleanor Murray

Panel members: Nicole Campos, Miguel Hernán, Jane Kim, Vidit Munshi, Eleanor Murray.

Host: Steve Resch

Click here to view the for March 2018 flyer

 

Do statins increase the survival of cancer patients?

Friday, February 2, 2018 | 3:45-5:30pm | Ballard Room, Countway Library

Co-hosted by the Program on Causal Inference, the Cancer Epidemiology Program, and the Harvard Chan Student Club on CANcer: Learn, Interact, Translate (CAN-LIT)

Over 25 million Americans take statins. While the cardiovascular benefits of statins are not under discussion, there is a debate as to whether statins increase the overall survival of cancer patients. This protective effect is biologically plausible and, in fact, reports from several observational studies have found an inverse association between statins and mortality among cancers patients. However, some of these studies did not explicitly emulate a randomized trial, which might have introduced selection bias and immortal time bias in the estimates. So do statins increase survival in cancer patients or is the inverse association due to bias? In this symposium we will address this question by discussing the available evidence on statins and mortality in cancer patients and will chart a research path forward.

Presentations by: Louise Emilsson, Hari Iyer, & Claire Pernar

Panel members: Barbra Dickerman, Louise Emilsson, Miguel Hernán, Hari Iyer, Lorelei Mucci, Claire Pernar.

Hosts: Joy Shi, Kevin Kensler

Click here to view the February 2018 flyer